Does Autonomic Function Link Social Position to Coronary Risk?

Does autonomic function link social position to coronary risk? The Whitehall II study.

BACKGROUND Laboratory and clinical studies suggest that the autonomic nervous system responds to chronic behavioral and psychosocial stressors with adverse metabolic consequences and that this may explain the relation between low social position and high coronary risk. We sought to test this hypothesis in a healthy occupational cohort. METHODS AND RESULTS This study comprised 2197 male civil ...

Sleep position, autonomic function, and arousal.

AIMS To investigate and compare heart rate variability (HRV) and responses of heart rate and arousal to head-up tilting in infants sleeping prone and supine. METHODS Thirty seven healthy infants aged 2-4 months were studied. HRV was measured for 500 beats while they were in a horizontal position. Subjects were then tilted 60 degrees head-up, and heart rate recorded over 1 minute and arousal r...

SRH and HrQOL: does social position impact differently on their link with health status?

BACKGROUND Self-rated Health (SRH) and health-related quality of life (HRQoL) are used to evaluate health disparities. Like all subjective measures of health, they are dependent on health expectations that are associated with socioeconomic characteristics. It is thus needed to analyse the influence played by socioeconomic position (SEP) on the relationship between these two indicators and healt...

Author's response to reviews Title: SRH and HrQOL: Does Social Position Impact Differently on Their Link with Health Status? Authors:

Protein Interaction Networks Link Schizophrenia Risk Loci to Synaptic Function

Schizophrenia is a severe and highly heritable psychiatric disorder affecting approximately 1% of the population. Genome-wide association studies have identified 108 independent genetic loci with genome-wide significance but their functional importance has yet to be elucidated. Here, we develop a novel strategy based on network analysis of protein-protein interactions (PPI) to infer biological ...